Katarina Varnäs Selected Research

AZD1390

12/2021	Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study.
1/2018	The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.

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Katarina Varnäs Research Topics

Disease

6	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 11/2009
5	Brain Neoplasms (Brain Tumor) 01/2021 - 10/2015
5	Parkinson Disease (Parkinson's Disease) 12/2020 - 04/2014
4	Mental Disorders (Mental Disorder) 01/2023 - 07/2004
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 12/2014
4	Neoplasms (Cancer) 12/2021 - 10/2016
4	Schizophrenia (Dementia Praecox) 01/2019 - 01/2008
2	Ataxia Telangiectasia (Louis Bar Syndrome) 12/2021 - 01/2018
2	Huntington Disease (Huntington's Disease) 01/2021 - 01/2017
2	Neoplasm Metastasis (Metastasis) 01/2021 - 10/2015
2	Epilepsy (Aura) 01/2020 - 10/2016
2	Psychotic Disorders (Schizoaffective Disorder) 01/2020 - 08/2008
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 10/2016
2	Lung Neoplasms (Lung Cancer) 01/2018 - 10/2015
2	Obesity 02/2016 - 03/2014
1	Gliosis 01/2023
1	Glioblastoma (Glioblastoma Multiforme) 12/2021
1	Treatment-Resistant Depressive Disorder 11/2021
1	Central Nervous System Diseases (CNS Diseases) 01/2018
1	Glioma (Gliomas) 01/2018
1	Major Depressive Disorder (Major Depressive Disorders) 09/2017
1	Disease Progression 10/2016
1	Weight Loss (Weight Reduction) 02/2016
1	Cognitive Dysfunction 01/2016
1	Neuroinflammatory Diseases 09/2015
1	Brain Diseases (Brain Disorder) 06/2015
1	Neuralgia (Stump Neuralgia) 04/2013
1	Prodromal Symptoms 04/2013
1	Cerebral Cortical Thinning 01/2008

Drug/Important Bio-Agent (IBA)

4	Serotonin (5 Hydroxytryptamine)IBA 01/2023 - 07/2004
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2009
3	Monoamine Oxidase (MAO)IBA 01/2023 - 01/2020
3	5-HT1B Serotonin ReceptorIBA 11/2021 - 07/2008
3	osimertinibIBA 01/2021 - 10/2016
3	Amyloid (Amyloid Fibrils)IBA 04/2013 - 11/2009
2	EnzymesIBA 01/2023 - 01/2019
2	AZD1390IBA 12/2021 - 01/2018
2	AfatinibIBA 01/2021 - 10/2016
2	Tyrosine Kinase InhibitorsIBA 01/2020 - 10/2016
2	ErbB Receptors (EGF Receptor)IBA 01/2020 - 10/2015
2	Metabotropic Glutamate 5 ReceptorIBA 01/2020 - 01/2018
2	AZD3241IBA 09/2015 - 06/2015
2	Peroxidase (Myeloperoxidase)IBA 09/2015 - 06/2015
2	2- (6- (methylamino)pyridin- 3- yl)- 1,3- benzothiazol- 6- olIBA 04/2013 - 11/2009
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 08/2009 - 08/2008
1	Protein Kinases (Protein Kinase)IBA 12/2021
1	Ketamine FDA LinkGeneric 11/2021
1	polyglutamineIBA 01/2021
1	pyrimidineIBA 01/2021
1	Fluorine-18IBA 12/2020
1	Carbon-11IBA 12/2020
1	Dopamine (Intropin)FDA LinkGeneric 12/2020
1	LigandsIBA 01/2020
1	fenobamIBA 01/2020
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2020
1	AZD9272IBA 01/2020
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2019
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2019
1	Glutamic Acid (Glutamate)FDA Link 01/2018
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	DNA (Deoxyribonucleic Acid)IBA 01/2018
1	Ataxia Telangiectasia Mutated ProteinsIBA 01/2018
1	Serotonin ReceptorsIBA 09/2017
1	Gefitinib (Iressa)FDA Link 10/2016
1	rociletinibIBA 10/2016
1	N- (3- (4- chlorophenyl)- 2- (3- cyanophenyl)- 1- methylpropyl)- 2- methyl- 2- ((5- (trifluoromethyl)pyridin- 2- yl)oxy)propanamideIBA 02/2016
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 02/2016
1	RimonabantIBA 02/2016
1	benzofuranIBA 01/2016
1	N,N- dimethyl- 7- (4- (2- (pyridin- 2- yl)ethyl)piperazin- 1- yl)benzofuran- 2- carboxamideIBA 01/2016
1	Investigational DrugsIBA 10/2015
1	AZD3759IBA 10/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2015
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 12/2014
1	Neurotransmitter Agents (Neurotransmitter)IBA 12/2014
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 03/2014
1	N- (2- tert- butyl- 1- ((4,4- difluorocyclohexyl)methyl)- 1H- benzo(d)imidazol- 5- yl)ethanesulfonamideIBA 04/2013
1	AZD2995IBA 04/2013
1	Amyloid beta-PeptidesIBA 10/2010
1	Antipsychotic Agents (Antipsychotics)IBA 01/2008

Therapy/Procedure

2	Radiotherapy 12/2021 - 01/2018
2	Therapeutics 01/2017 - 04/2013
1	Drug Therapy (Chemotherapy) 01/2018
1	Aftercare (After-Treatment) 09/2015